New Case Report: Intra-procedural evaluation of Computational Modeling Method for CRT

Buliard et al., Intra-procedural evaluation of a computational modelling method for cardiac resynchronization therapy, EP Europace, Volume 22, Issue 4, April 2020, Page 656,

With the team we developed a way to measure response to cardiac resynchronization therapy (CRT). CRT is a common tool used in cardiac electrophysiology (CEP), but it relies on perfect placement of the left ventricular (LV) lead. Our research team has been working on a project that evaluates how simulations can be incorporated into CEP for better lead implantation. Our case report, published in EP Europace, explores the guidance of LV lead implantation using intra-procedural CEP simulations.

To do this, we first made a computational model of CEP based on each individual patient’s cardiac MRI and ECG about one day before the CRT. During the procedure, we implanted a CRT system with a quadripolar LV lead. Using each patient’s individual data, we updated the model. We were able to sense ventricular delays and epicardial activation. We changed LV lead positions and AV delays to evaluate 6 different CRT protocols. We then simulated CRT.

We found that there was excellent agreement between the actual QRS duration and the QRS duration we had predicted. These results show that it could be possible to use computational simulations of CEP intraprocedurally to guide CRT!

New Jersey 2019 Edison Patent Award

In Fall of 2019, my colleagues and I had the honor to win the New Jersey Edison Patent Award for our work on modeling a human heart.

While modeling a heart on a computer sounds complicated, we started simply. First, we used images to model the geometry and anatomy of the heart. We then used patient data on top of data gathered from imaging, such as ultrasounds, electrocardiograms, and magnetic resonance imaging. The result is a realistic computer model of a human heart.

As detailed in the video, our model behaves as close as possible to a real human heart. This allows us to perform virtual therapies to figure out what types of interventions would work best on a real human heart. We could test different settings, different electrode placements, and other simulated interventions to understand how the heart behaves under these different conditions.

We are honored to have been chosen for the Edison Patent Award. A big congratulations to the entire team!